The event marks the start of Air Ambulance Week and the 600 cyclists taking part have the option of an 11-mile or 55 mile route.
Claire Alers-Hankey, George Bone, Fiona Laramy, and Catherine Wood will all be setting off from Washford in West Somerset and embarking on the 55-mile route ending in West Bay in Dorset.
They hope to complete the challenge in around five to six hours depending on conditions.
The event is a crucial fundraiser for the charity, which had to be postponed last year because of the pandemic.
It is the only fundraising event run directly by the air ambulance charity and they are urging participants to raise funds through sponsorship.
Greenslade Taylor Hunt will be supporting this vital cause by contributing towards the efforts of the firm’s four cyclists.
The event is a challenge rather than a race and so attracts cyclists of all ages and abilities.
To find out how to support the air ambulance please visit email@example.com